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SpacePharma’s Microgravity Labs Augur Drug Breakthroughs Of The Future

Earlier this week, a bio laboratory containing four science experiments arrived at the International Space Station. The lab is housed inside a box the size of a milk carton, and the research trials–which will be conducted via a remotely controlled, Wi-Fi-connected web or phone app–have already begun.

Testing drugs in outer space sounds like the very definition of a trip, but it’s not that uncommon for major pharmaceutical companies. Merck, Procter & Gamble, and Eli Lilly have all conducted tests on the International Space Station over the past decade. And by the end of this year, more rodents will have left the Earth’s orbit than any other mammal thanks to the expanding potential of microgravity testing in pharmaceutical development.

Science in space is now a $3 billion industry, according to Reuters, and it’s barely even taken off: The volume and depth of microgravity research has been limited by the high cost of getting into orbit. Now, thanks to the falling cost of rocket launches, the miniaturization of lab equipment, and the proliferation of smaller commercial space enterprises catering to space entrepreneurs, small-scale microgravity experiments are becoming more accessible.

The Cygnus spacecraft is pictured after it had been grappled with the Canadarm2 robotic arm by astronauts Paolo Nespoli and Randy Bresnik on Nov. 14, 2017. [Photo: NASA]

The lab that docked with ISS this week was built by a leading startup in the microgravity research field, the Swiss-Israeli company SpacePharma. For around $230,000, clients can rent one of the company’s minilabs for up to six months of orbital research. But it’s not the labs that customers are buying so much as the access to gravitational conditions that can’t be replicated on Earth.

“Extreme conditions can change a researcher’s perspective on how reactions take place,” says CEO Yossi Yamin, a former commander of the Israeli Defense Force’s satellite unit. “When there are no G forces, everything grows and reacts much more clearly than on Earth.”

Microgravity can teach us new things about our genes, our medicines, and the chemicals we use every day on Earth. Proteins crystallize differently, molecules take on different shapes, and there’s less atmospheric “noise” to get in the way of, say, enzymatic reactions, or bacterial growth. In space, the physics are simpler, so scientists can work with fundamental equations.

“When you take gravity out of the equation, all your intuitions about the processes underlying the experiment are different,” explains Julie Robinson, NASA’s chief scientist at the International Space Station. “There are two processes you don’t get on earth: buoyancy and density-driven convection. The way to think about buoyancy is if you’re boiling a pot of water, bubbles rise at top of the pot. That mixing is turbulent, so the physics are a beast.”

[Screenshot: courtesy of SpacePharma]

SpacePharma, which is headquartered in Switzerland near Basel’s booming biotech sector but also has an outpost in Palo Alto, CA., is currently working with the Philadelphia Children’s Hospital to send lung cells into space for immune response reaction testing early next year. The startup’s clients also include universities and private companies. SpacePharma uses the ISS to dock some of its labs, but its units can also be attached to private satellites.

This allows SpacePharma to send liquid into free orbit, which is unusual according to Yamin, and to place no limits on potentially hazardous substances, like certain kinds of bacteria. “Most of the time astronauts have to think about their health, do safety and machine checks, and work on other missions; they’re not allowed to spend too much time on this,” Yamin says. “With us, you can skip and cut the middlemen, and make it directly so scientists can control the experiment. That saves significant labor costs.”

[Screenshot: courtesy of SpacePharma]

The more traditional route to space is through publicly funded programs. In the U.S, the Center for the Advancement of Science in Space, or CASIS–a nonprofit funded by the government that oversees activities on the International Space Station–says it is actively seeking partners and participants. The operating costs depend largely on the nature of the research, but thanks to various sources of funding, “it’s not as cost prohibitive as you’d think” says Mike Roberts, CASIS’s deputy chief scientist (you’d still have to apply for the funding, which takes time.)

These tests have already produced tangible results. Merck, the pharmaceutical giant, ran tests to enhance the effects of a cancer drug named Keytruda. Amgen developed Prolia, an osteoporosis drug, after gathering data from tests on cosmonaut mice. A materials company called Milliken & Co used space to make better flame retardant textiles to protect first responders. And the retailer Target is offering a million dollars to the best proposal on how to enhance cotton sustainability through microgravity experiments on the ISS.

The experiments can get appropriately weird: According to Roberts, when a scientist working for NASA sent flatworms up to test the regenerative properties of their tissues, some grew back two heads instead of one. When these worms reproduced in space, their offspring also grew extra heads.

Nexus-lab hardware [Photo: courtesy of Tom Kyler, Space Technology and Advanced Research Systems, Inc./NASA]

Gene expression–when the information stored in our DNA gets turned into proteins–behaves differently, and can be analyzed more effectively in space.”60.5 % of genes aren’t expressed appropriately on Earth,” says Yamin, “but in microgravity we can detect those genes and bring the data back to earth.”

SpacePharma currently employs 12 people (three systems engineers, three software engineers, and three science PhDs) and Yamin expects his company to double in size in the next couple of years as healthcare becomes more personalized. He envisions SpacePharma helping wealthy people and small groups of individuals run their own specialized tests targeting rare diseases.

“This is a change we’re experiencing in the industry. You don’t need big markets, you need tailored, small ones,” he says. “If 200 people who have the same rare disease find each other on Facebook and decide they want to survive together, they can bring $1000 each, take their problem to a scientist, and continue testing from this point.”

In exchange, SpacePharma claims a fraction of the royalties that might be derived from a discovery down the line. The intellectual property derived from experiments belongs to the researchers.

[Screenshot: courtesy of SpacePharma]

The same is true of research conducted through the government-funded CASIS, which has overseen more than 200 research projects in microgravity since 2011, and its scientists are eager to do more: 50 percent of the capabilities on the ISS are in service of the private sector, with the other half managed by NASA to work on exploration projects.

SpacePharma’s advantage is that its clients don’t need to obtain grants from a university or a government, or to play by ISS rules at all if they simply want to experiment in microgravity.

NASA and CASIS see their mission as working in tandem with private sector clients and service providers, and for all his talk of bypassing regulation, Yamin doesn’t disagree; in fact, SpacePharma itself was conceived after he and his partners brainstormed with officials at NASA and the European Space Agency and concluded that what they could offer was a streamlined process for launching experiments “with less registration and bureaucracy.”

“It’s not a competition [with private business] at all,” says Roberts, running of the names of businesses they’ve partnered with: Nanoracks, another firm launching scientific experiments into space, and Space Tango, which does similar work on the International Space Station.

“Someday, the Space Station will wear out, and we want low earth orbit to become part of the U.S economy,” says Julie Robinson. “For that we need companies to build capacity to operate without government support at the level we have it today.”

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